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在开始抗逆转录病毒治疗之前,我们是否需要进行常规的整合酶耐药性测试?
Rami Kantor1, Alice K Pau2, Michael J Kozal3
1Division of Infectious Diseases, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA; The Miriam Hospital, Providence, RI, USA.
The lancet. HIV
|June 20, 2025
概括
第二代整合酶链转移抑制剂对于艾滋病毒治疗至关重要. 需要对传递整合酶耐药性的进一步研究,以指导临床决策并保护这种药物类别.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 口服第二代整合酶链转移抑制剂 (INSTIs) 是全球抗逆转录病毒疗法 (ART) 的基石,原因是耐药性高.
- 高收入国家目前的指导方针建议进行常规的蛋白酶和逆转录酶耐药性测试,但整合酶耐药性测试只适用于高风险人群.
- 在启动ART之前,关于整合酶耐药性测试的最佳策略存在不确定性.
研究的目的:
- 突出描述传递整合酶抗性的重要性.
- 为未来的临床决策和INSTI-based ART的指导方针制定提供信息.
- 为应对平衡药物类别保护与资源配置和护理复杂性的挑战.
主要方法:
- 本摘要讨论了当前在ART中抗性测试的情况.
- 它强调需要改进传递整合酶抵抗的特征.
- 它要求提供者,研究人员和政策制定者参与其中.
主要成果:
- 传递整合酶耐药性特征,检测和临床影响需要进一步调查.
- 在开始ART之前对整合酶耐药性测试的当前指导方针可能需要重新评估.
- 整合酶耐药性测试的最佳方法是一个重大挑战.
结论:
- 对传递整合酶耐药性的进一步研究对于指导临床实践至关重要.
- 提供者在决定何时以及是否进行整合酶耐药性测试时面临挑战.
- 需要共同努力来解决对整合酶抵抗及其管理的不断变化的理解.
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