在I-IV期乳腺癌患者的化疗治疗期间葡萄糖水平的变化
Patrick M Schnell1, Mahmoud Kassem2, Abdul Miah2
1Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH.
Clinical breast cancer
|June 20, 2025
概括
化疗在乳腺癌患者的血糖水平略有下降,但个体变化有所不同. 基线葡萄糖,年龄和特定的化疗方案,如多塞塔克塞尔/cyclophosphamide影响了这些葡萄糖水平的变化.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 临床化学 临床化学
背景情况:
- 葡萄糖失调是乳腺癌化疗期间的潜在并发症,影响患者的发病率和死亡率.
- 虽然葡萄糖失调的机制已知,但化疗的具体影响仍然不清楚.
- 关于化疗对乳腺癌患者葡萄糖水平的影响的先前研究产生了相互矛盾的结果.
研究的目的:
- 在接受化疗的乳腺癌妇女中研究血糖水平的变化.
- 探索各种共变量对化疗诱导的葡萄糖变化的影响.
- 通过分析特定的患者亚组,调和先前研究的不一致结果.
主要方法:
- 追溯分析981名在2016年至2018年期间接受治疗的I-IV期乳腺癌患者.
- 对血糖水平的评估,以及临床和组织病理学数据.
- 进行了子组分析,以将调查结果与以前的报告进行比较.
主要成果:
- 整体而言,在化疗后观察到血糖水平略有下降 (131.3 mg/dL vs. 134.8 mg/dL,P = .048).
- 基线血糖<125 mg/dL的患者经历了血糖水平的增加 (113 mg/dL与99 mg/dL相比,P <.001).
- 与其他疗法相比,多塞塔塞尔/cyclophosphamide疗法与基线葡萄糖估计增加更大 (P < .001).
结论:
- 化疗导致随机血糖水平的适度降低.
- 之前的研究中的差异很可能是由于研究患者群体的变化.
- 基线葡萄糖,患者年龄和特定的化疗方案是治疗期间葡萄糖水平变化的关键预测因素.
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