病毒诱导的细胞衰老会导致流感感染后的肺部后果
Larissa Lipskaia1,2, Lou Delval3, Valentin Sencio3
1Institut Mondor de Recherche Biomédicale (IMRB), FHU SENEC, Univ. Paris-Est Créteil, INSERM U955, Créteil, France.
流感病毒感染会通过细胞衰老引起肺部损伤. 用药物准这些衰老细胞加速了肺部的修复,并可能为流感后续提供新的治疗选择.
科学领域:
- 肺部医学 肺部医学
- 病毒学 病毒学
- 细胞生物学 细胞生物学
背景情况:
- 流感A病毒 (IAV) 感染可能导致急性和慢性肺损伤.
- 细胞衰老,一种不可逆转的细胞循环停止状态,已与各种与衰老相关的疾病有关.
研究的目的:
- 调查IAV诱导的细胞衰老是否有助于长期的肺部变化.
- 探索针对流感引起的肺损伤中衰老细胞的治疗潜力.
主要方法:
- 鼠被感染H1N1p2009 IAV,并对细胞衰老的标志物进行分析 (p16,p21,β-galactosidase,gamma-H2A.X).
- 使用了衰老细胞的遗传衰竭 (p16-ATTAC小鼠接受AP20187治疗) 和用老化药物 (ABT-263) 进行药理治疗.
- 肺组织重塑,上皮完整性,肺气和纤维化在感染后的不同时间点进行了评估.
主要成果:
- IAV感染诱导支气管上皮和肺外皮细胞衰老,病毒清除后持续很长时间.
- 持续衰老的细胞与呼吸道上皮质磨损,肺重塑,肺和纤维化有关.
- 衰老细胞的枯竭或使用衰老药物的治疗加速了呼吸道上皮质的修复和改善了肺部结构,独立于病毒清除.
结论:
- 病毒诱导的衰老细胞在流感的长期肺部后果中发挥着关键作用.
- 向衰老细胞是缓解流感相关肺损伤和促进修复的有希望的治疗策略.
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