在不考虑生物学和权衡的情况下降低曝光率不是预防性的
Richard A Williams1, Edward J Calabrese2
1Center for Truth in Science, FDA Retired and University of Massachusetts, 13266 Fieldstone Way, Gainesville, VA, 20155, USA.
Chemico-biological interactions
|June 20, 2025
概括
现代毒理学和风险评估经常忽视有益的适应机制和内源性毒素生产. 这可能会导致整体损害增加,因为忽视了权衡,专注于过时的预防原则.
科学领域:
- 环境毒理学环境毒理学
- 风险评估科学 风险评估科学
- 监管政策分析 监管政策分析
背景情况:
- 当前的法规和有毒侵权行为依赖于过时的预防原则.
- 关于内源性毒素产生和适应性健康机制的关键科学发现经常被忽视.
- 政策可能会忽视阻碍性影响,这种影响可以是有益的或适应性的.
研究的目的:
- 检查风险评估中低剂量决策的历史基础.
- 分析预防原则如何影响监管和法律决策.
- 突出忽视科学发展和权衡可能造成的潜在危害.
主要方法:
- 风险评估政策和有毒诉讼决策的历史审查.
- 关于内源性毒素,适应机制和hormesis的科学文献分析.
- 对致癌物质的线性无值 (LNT) 剂量反应模型的检查.
主要成果:
- 预防原则的应用往往导致政策不考虑有益的生物反应.
- 像环保署这样的监管机构排除适应性或有益影响可能会导致意想不到的后果.
- 忽视对冲风险和对不同亚群体的影响,可能会导致整体损害增加.
结论:
- 过时的监管方法可能会造成比预期的更大的伤害,因为它们忽视了科学进步.
- 需要对风险评估框架进行重新评估,以纳入内源因素和适应性反应.
- 考虑所有受影响的子群体和权衡对于有效和安全的风险管理至关重要.
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