叶酸摄入量与自杀念头之间的关联:NHANES 2005-2018和孟德尔随机化
Ling Feng1, Shandie Li1, Chaorui Li2
1School of Public Health, Chongqing Medical University, Chongqing, China.
Journal of affective disorders
|June 20, 2025
概括
较高的叶酸摄入量可能会降低自杀念头的风险,但没有证实因果关系. 这项研究使用NHANES数据和门德尔随机化探索了这种关联. 需要进一步的研究来确定因果关系.
科学领域:
- 营养精神病学 营养精神病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 以前的研究表明,叶酸摄入量和自杀行为之间存在联系.
- 叶酸摄入量对自杀念头的具体影响尚不清楚.
- 这项研究旨在澄清叶酸消费与自杀念头之间的关系.
研究的目的:
- 调查叶酸摄入量与自杀念头之间的关联.
- 使用孟德尔随机化探索潜在的因果关系.
- 分析各种人口和健康子组之间的关系.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 数据库 (2005-2018) 的数据.
- 采用加权后勤回归,限制立方线 (RCS) 模型和子组分析.
- 应用孟德尔随机化 (MR) 来评估潜在的因果关系.
主要成果:
- 在叶酸摄入量和自杀念头之间发现了一个非线性反向关系 (P=0.014).
- 与最低四分位数相比,较高的叶酸摄入量 (第四四分位数) 与38%的自杀想法风险降低有关.
- 这种关联在各个子组中是一致的,但MR分析没有确定因果关系 (P=0.533).
结论:
- 叶酸摄入量和自杀念头之间存在反向关联.
- 在这项研究中,叶酸摄入量和自杀念头之间没有因果关系.
- 需要进一步的研究,以了解叶酸与心理健康之间的复杂相互作用.
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