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相关概念视频

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

5.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
5.8K
T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

2.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
2.5K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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相关实验视频

Updated: Sep 18, 2025

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

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缺铁导致CD8+ T细胞中阿斯巴酸盐敏感功能障碍.

Megan R Teh1,2, Nancy Gudgeon3, Joe N Frost4

  • 1MRC Translational Immune Discovery Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. mteh@cemm.oeaw.ac.at.

Nature communications
|June 20, 2025
PubMed
概括

缺铁会通过破坏线粒体代谢来阻止CD8+T细胞的增殖. 提供阿斯巴酸盐可以挽救T细胞扩张和功能,为免疫功能损害提供潜在的治疗策略.

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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Generation of Human Alloantigen-specific T Cells from Peripheral Blood

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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相关实验视频

Last Updated: Sep 18, 2025

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

439
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09:47

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞的新陈代谢
  • 营养生物化学 营养生物化学

背景情况:

  • 铁对于细胞代谢和免疫功能至关重要.
  • 全球超过10亿人患有铁缺乏症,免疫力受损.
  • 缺铁对CD8+T细胞功能的确切影响尚不清楚.

研究的目的:

  • 为了研究低铁的可用性如何影响CD8+T细胞代谢和功能.
  • 阐明在缺铁时免疫功能下降的分子机制.

主要方法:

  • 多原子分析 (基因组学,转录组学,蛋白质组学).
  • 代谢标签技术.代谢标签技术.
  • 评估线粒体功能和细胞增殖.

主要成果:

  • 铁的限制显著损害了CD8+ T细胞的增殖和线粒体膜潜力.
  • TCA循环代谢发生变化,转向减少轨迹.
  • 亚斯巴酸盐会积累,但由于线粒体功能障碍,它不能用于核酸合成.
  • 外源性阿斯巴酸部分地挽救了CD8+T细胞的扩张和功能.

结论:

  • 缺铁会在线粒体中产生代谢瓶,阻碍CD8+ T细胞的功能.
  • 酸盐补充剂可以绕过这个瓶,恢复一些免疫细胞的能力.
  • 这些发现提供了对铁缺乏引起的免疫功能障碍的机制性见解.