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Updated: Sep 18, 2025

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定义生物PROTACs效率的分子特征

Dorothea Winkelvoß1, David Vukovic1, Anna-Carina Hänny1

  • 1Department of Biochemistry, University of Zurich, Zurich, Switzerland.

Communications biology
|June 20, 2025
PubMed
概括

研究人员探索了生物PROTACs,揭示了最佳的目标泛化和蛋白酶体呈现,而不仅仅是结合亲和力,是有效降解蛋白质的关键. 本研究提供了优化生物PROTAC系统的设计原则.

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