与线索利德相关的低血症的危险因素集中在静脉注射和口服之间的差异上:单中心,回顾性研究
Ryoji Takata1, Masatoshi Taga2, Hirofumi Nagai2
1Department of Pharmacy, Kanazawa Medical University Hospital, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa, 920-0293, Japan. ryoji-t@kanazawa-med.ac.jp.
与口服相比,静脉注射线索利德 (LZD) 显著增加了低血症的风险. 患有风险因素的患者需要在LZD治疗期间仔细监测血清水平.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 线化物 (LZD) 相关的低血症是一种罕见但严重的不良反应.
- 之前的研究没有将静脉注射 (IV) 与口服LZD相比较,关于低血风险.
- 这项研究调查了LZD诱导的低血症的风险因素和给药途径差异.
研究的目的:
- 为了确定与线索利德相关的低血症的独立风险因素.
- 为了比较IV和口服linezolid管理之间的低血症的发生率.
- 为了告知临床实践关于安全使用linezolid.
主要方法:
- 对患者 (≥20年) 接受1200毫克/天静脉注射或口服线索利德的回顾性研究 (2011年1月至2023年12月).
- 多重后勤回归分析以确定低血症的危险因素.
- 倾向性得分匹配,以比较服用途径之间的低血症发病率.
主要成果:
- 低血症发生在13.3% (32/240) 的患者中.
- 独立的风险因素包括静脉注射 (OR=17.1),基线血清水平较低,肌素清除率较低.
- 在倾向分数匹配后,IV线索利德显示了显著更高的低血症发病率 (OR=9.7).
结论:
- 静脉注射线索利德是低血的独立危险因素.
- 与口服linezolid相比,IV治疗的低血症风险明显高.
- 建议在接受IV线索的患者中谨慎和密切监测血清,特别是那些具有已确定的风险因素的患者.
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