母婴喘与儿童自闭症之间的关联:系统性审查和元分析
Renee van der Schaaf1,2, Vanessa E Murphy3,4, Soriah Harvey3,4
1School of Psychological Sciences, University of Newcastle, Newcastle, New South Wales, Australia.
概括
怀孕期间母亲喘与儿童自闭症的可能性更高有关. 这项系统性审查发现,母亲患有喘的儿童患自闭症的几率增加,尤其是在使用药物时.
科学领域:
- 生殖健康 生殖健康
- 发育神经科学的发展神经科学.
- 流行病学 流行病学
背景情况:
- 性喘与儿童的自闭症谱系障碍 (ASD) 有关.
- 了解这种潜在的关联对于公共卫生和早期干预策略至关重要.
研究的目的:
- 系统地审查和分析调查孕期母亲喘与儿童自闭症风险之间的关联的观察性研究.
- 量化母亲患有喘的孩子患自闭症的几率,考虑药物使用等因素.
主要方法:
- 针对2001年7月至2024年2月期间发表的研究,在MEDLINE,CINAHL,EMBASE和PsycINFO进行了系统的文献搜索.
- 十九项观察性研究 (n=2,530,716) 符合纳入标准,其质量使用纽卡斯尔-太华尺度进行评估.
- 使用随机效应模型进行了元分析,以计算与母亲喘和药物使用有关的儿童自闭症的几率比率 (OR).
主要成果:
- 母亲喘与儿童自闭症的几率增加有关 (OR=1.32;95% CI=1.21,1.44).
- 怀孕期间目前的喘 (OR=1.23;95% CI=1.12,1.35) 和使用喘药物 (OR=1.48;95% CI=1.30,1.68) 也显示增加了几率.
- 在使用和不使用喘药物的母亲之间,没有发现自闭症几率的显著差异 (OR=1.07;95% CI=0.89,1.27).
结论:
- 怀孕期间母亲喘与儿童自闭症风险增加有显著的关联.
- 进一步的研究应该探索父母的神经分歧,喘严重程度和药物有效性,以阐明这种关联.
- 这些发现凸显了怀孕期间母亲健康管理对儿童神经发育结果的重要性.
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