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Updated: Sep 18, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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通过CRE结合蛋白 (CREB) 介导的cAMP-响应元件 (CRE) 转录对于人类基酶2基因表达至关重要

Yukino Nawa1, Hanae Kaneko1, Masaaki Tsubonoya1

  • 1Institute of Radioisotope Research, St. Marianna University Graduate School of Medicine, Kawasaki, Kanagawa, Japan.

Journal of neurochemistry
|June 21, 2025
PubMed
概括

这项研究揭示了cAMP信号如何激活人体基酶2 (hTPH2) 基因表达. 蛋白激酶A (PKA) 和CRE结合蛋白 (CREB) 是关键的调节剂,其中CRTC1增强了对神经精神疾病的转录.

关键词:
通过CREB监管的转录辅助激活器 (CRTC).这是一种CRE结合蛋白 (CREB).cAMP 响应元件 (CRE) 的使用.这种神经元是塞罗托尼基神经元.转录规则 转录规则 转录规则托芬氧化酶2托芬氧化酶2

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