相关实验视频

Updated: Sep 18, 2025

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

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通过抑制LINE-1表达,HELQ保持了原始生殖细胞的基因组稳定性

Lili Cao1,2,3,4,5,6,7, Jiayi Ren1,2,3,4,5,6,7, Zhaojie Kong1,2,3,4,5,6,7

  • 1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|June 21, 2025
PubMed
概括

缺少DNA螺旋酶HELQ会通过增加LINE-1逆转移素的表达来损害原始生殖细胞 (PGC) 的增殖,从而影响生殖储备. 这项研究揭示了HELQQ.

关键词:
对DNA损伤的反应反应这就是HELQQ.线路-1 线路-1 线路原始的生殖细胞.反向转换反向转换的位置

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Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans07:53

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