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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

675
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
429
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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相关实验视频

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Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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在固体瘤治疗中用于代码输送的甘氨酸聚合物.

Yuan-Peng Wang1,2, Xiao-Ke Ren1,2, Qing-Lin Sun1,2

  • 1Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, PR China.

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概括

这项研究引入了超分子纳米囊,用于在非小细胞肺癌中共同输送多克索鲁比和氧沙. 这种方法增强了药物协同作用,并减少了与传统组合化疗相比的毒性.

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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相关实验视频

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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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科学领域:

  • 在瘤学瘤学.
  • 纳米医学是一种纳米医学.
  • 药物运输 药物运输 药物运输

背景情况:

  • 多组分化疗对于非小细胞肺癌 (NSCLC) 是至关重要的.
  • 目前的组合化疗缺乏协同药物活性.
  • 在最大限度地减少毒性时实现协同效应仍然是一个挑战.

研究的目的:

  • 开发一种用于增强协同化疗的新型药物输送系统.
  • 通过使用超分子纳米囊来研究多克索鲁比和氧沙的配送.
  • 为了评估这个纳米载体系统的有效性和安全性.

主要方法:

  • 超分子纳米囊是使用Cucurbit[8]uril.制造的.
  • doxorubicin 和oxaliplatin 通过非共价相互作用进行封装.
  • 细胞毒性和器官毒性在体外和体内被评估.

主要成果:

  • 纳米囊配方显示了对癌细胞的增强细胞毒性.
  • 与免费药物组合相比,协同效应显著更高.
  • 观察到对正常器官的毒性影响减少.

结论:

  • 高分子纳米囊为协同化疗提供了一个有前途的平台.
  • 这种方法可以改善非小细胞肺癌的治疗结果.
  • 通过纳米囊进行代码输送为组合化疗方案提供了一种新的策略.