VEGF+405C/G多态与胃肠道癌症风险的相关性:更新的元分析
Sukhpreet Kaur Walia1, Vasudha Sambyal1, Kamlesh Guleria1
1Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
Asian Pacific journal of cancer prevention : APJCP
|June 21, 2025
概括
血管内皮生长因子 (VEGF) +405C/G多态可能表明食道,结肠直肠和胰腺癌的风险. 这一元分析澄清了与其与胃肠道癌症风险相关的不一致的发现.
科学领域:
- 遗传学和分子生物学
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
背景情况:
- 血管内皮生长因子 (VEGF) 功能多态性影响血管新生和瘤发育.
- 之前关于VEGF+405C/G多态化与胃肠癌风险相关的研究结果不一致.
- 需要进行元分析来澄清这种多态性在肠道癌症发展中的作用.
研究的目的:
- 进行全面的元分析,澄清VEGF+405C/G多态与患胃肠道癌症的风险之间的关联.
- 评估总体关联和基于种族和癌症类型的分层分析.
主要方法:
- 在PubMed,谷歌学者,科学网和科学直接进行了系统的文献搜索.
- 来自23项研究的数据,包括5656例病例和6319例对照,使用MetaGenyo软件提取和分析.
- 应用了包含和排除标准,以确保所选研究的质量和相关性.
主要成果:
- 总体分析和种族分层分析没有显示VEGF+405C/G多态和整体肠道癌症风险之间存在显著的关联.
- 在几种遗传模型下,子组分析表明与食道癌风险增加存在显著关联.
- 具体模型显示,与食道癌风险降低和结直肠和胰腺癌风险改变有显著关联.
结论:
- 维格F+405C/G多态可能作为评估个体癌症风险的潜在生物标志物.
- 这些发现表明这种多态性在患食道,结肠直肠和胰腺癌的风险中起着特定的作用.
- 这一元分析为VEGF遗传变异与肠道癌症易感性之间的复杂关系提供了宝贵的见解.
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