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迪奥斯基宁的抗癌潜力,一个类固醇沙宁,对人类口腔癌细胞

Uma Dutta¹, Sonali Dey¹, Monikongkona Boruah²

¹Cell and Molecular Biology, Toxicology Laboratory, Department of Zoology, Cotton University, Guwahati, Assam, India.

Asian Pacific journal of cancer prevention : APJCP

|June 21, 2025

概括

天然化合物迪奥斯基宁在治疗口腔状细胞癌 (OSCC) 方面表现有前途,通过抑制癌细胞的生长和迁移. 它还增强了现有的化疗药物对OSCC的有效性.

科学领域:

在瘤学瘤学.
自然产品化学自然产品化学
分子生物学分子生物学

背景情况:

口腔状细胞癌 (OSCC) 是全球流行的一种癌症,印度东北部的发病率很高.
目前的手术和化疗等治疗方法存在局限性,包括副作用和对诸如西斯和5-甲 (5-FU) 等药物的化学抵抗.
迪奥斯基宁,一种类固醇的素,正在研究其潜在的治疗效果.

研究的目的:

为了研究体内迪奥斯基宁对OSCC细胞的存活,增殖和迁移的影响.
评估迪奥斯基宁对OSCC细胞对西斯丁和5-FU的化学敏感性的影响.
评估迪奥斯基宁对参与OSCC进展的关键蛋白质的表达的影响.

主要方法:

在体外测试包括MTT,殖民地形成,细胞周期分析 (PI-FACS),活/死染色和伤口愈合测试.
西部斑点分析用于评估与OSCC相关的关键蛋白质的表达.
在OSCC细胞系 (SAS,HSC3) 和正常细胞系 (HEK-293T) 上测试了迪奥斯基宁的作用.

主要成果:

迪奥斯基宁对OSCC细胞系 (SAS,HSC3) 具有选择性抗增殖活性,但对正常的HEK-293T细胞没有.
迪奥斯基宁增强了SAS细胞对思丁和5-FU的化学敏感性.
该化合物对SAS细胞表现出剂量依赖的抗克隆原,细胞循环停止,细胞毒性和抗迁移作用,并调节了关键OSCC蛋白 (COX-2,CXCR-4,VEGF,TWIST-1,p-AKT,AKT).

结论:

迪奥斯基宁在治疗口腔癌方面显示出显著的治疗潜力.
这些发现表明迪奥斯基宁是新型口腔癌治疗的有希望的候选者.
需要在体内和临床环境中进一步验证.

关键词:

5 - - 甲酸是一种5甲.西斯普拉丁 (Cisplatin) 是一种这是OSCCCC的OSCC.化学敏感性化学敏感性在 diosgenin 的基础上.

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