瘤科医生和他们的病人是否在同一页上? - 探索临床医生与患者在绩效状态报告中的协议
Nandini Devi Rajan1, Praveen Kumar Shenoy2, Mohandoss Murugesan3
1Department of Clinical Haematology and Medical Oncology, Malabar Cancer Centre (PGIOSR), Thalassery, Kerala, 670103, India.
概括
临床医师绩效状况 (cPS) 比患者评估 (pPS) 更好地预测化疗致病率,尽管两者之间协议较弱. 一个新的"平均PS"得分显示了未来验证预测患者结果的希望.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 患者的治疗结果.
背景情况:
- 临床医师评估的绩效状态 (cPS) 是癌症患者发病率的关键预测因素.
- 在临床评估中,患者对绩效状态 (pPS) 的观点往往缺失.
- cPS和pPS之间的差异可能会影响结果预测.
研究的目的:
- 评估临床医生评估绩效状态 (cPS) 和患者评估绩效状态 (pPS) 之间的一致性.
- 为了确定哪种评估 (cPS或pPS) 更好地预测接受化疗的癌症患者的30天病率.
- 为了探索"平均PS"分数的预测价值,将这两种评估结合起来.
主要方法:
- 对215名接受固体瘤第一周期细胞毒性化疗的患者进行前性观察性研究.
- 用于临床医生 (cPS) 和患者 (pPS) 评估的ECOG绩效状态问卷.
- 监测30天的发病率,住院和3-4级毒性;计算"平均PS".
主要成果:
- 在cPS和pPS之间观察到较弱的协议 (14.65%的协议,kappa=0.042).
- 平均pPS高于平均cPS (1.62对1.31).
- 临床医师评估的绩效状态 (cPS) 显著预测了30天的发病率和毒性; "平均PS"也显示了显著的关联.
结论:
- 临床医生评估的绩效状况仍然是化疗相关发病率和毒性的主要预测因素.
- 小说"平均PS"提供了一种简单的方法来整合患者的观点.
- 在更大的队列中进一步验证"平均PS"是合理的.
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