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Updated: Sep 18, 2025

Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain
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通过有条件疼痛调制评估的内源性止痛,与对照人群相比,关节骨质炎患者的表现并不不同:一个横截面研究

Myles C Murphy1, Molly Coventry2, Ebonie K Rio3

  • 1Nutrition and Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Institute for Health Research, The University of Notre Dame Australia, Fremantle, Western Australia, Australia.

Musculoskeletal science & practice
|June 21, 2025
PubMed
概括

患有关节骨关节炎的人表现出局部机械疼痛敏感性增加,但没有广泛的敏感性. 条件疼痛调制 (CPM) 在各组之间没有差异,这表明关节骨关节炎疼痛感知局部变化.

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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