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在哺乳期期间,母亲的免疫激活会改变小鼠的后代行为,生殖发育和免疫功能

Jailyn A Merengueli¹, Amanda C Kentner¹

¹School of Arts & Sciences, Health Psychology Program, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, United States.

Hormones and behavior

|June 21, 2025

概括

母亲免疫激活 (MIA) 在小鼠哺乳期间,由感染引起,改变后代的神经发育和免疫功能到成年. 这凸显了在关键的哺乳期内母亲健康的重要性.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
发展生物学发展生物学

背景情况:

早期的感染可能会导致长期的神经发育变化.
孕产妇免疫激活 (MIA) 模型通常侧重于产前暴露.
哺乳期感染也会影响后代的神经发育.

研究的目的:

研究哺乳期MIA对后代神经行为和免疫功能的影响.
为了适应大鼠MIA模型在小鼠中使用.
评估产后母亲感染的长期后果.

主要方法:

哺乳C57BL/6J小鼠母亲在产后第8天接受了脂多糖 (LPS) 或盐水的挑战.
在新生儿,青少年和成人阶段评估后代的神经行为.
在第二次LPS挑战后,在成年后评估了免疫功能.

主要成果:

哺乳期MIA并没有影响母亲的护理,但引起了母亲的疾病.
新生儿后代的行为没有受到影响.
青少年和成年后代表现出改变的社会偏好,生殖里程碑,疼痛敏感性和感官门.
成人后代对二次LPS挑战的免疫反应发生了变化.

结论:

哺乳期MIA是跨物种有效的模型,用于研究感染诱导的神经发育影响.
产后母亲感染可能对后代的神经发育和免疫编程产生长期影响.
在哺乳期支持母亲的健康对于后代的福祉至关重要.

关键词:

哺乳期哺乳期是一个孕产妇的免疫激活护理护理护理编程编程编程编程第二次击中.

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