高压氧对UCB移植后输血和生长因子支持的高压氧的影响
Haitham Abdelhakim1, Ahmed Hebishy2, Leyla Shune1
1The University of Kansas Medical Center, Kansas City, KS, United States; The University of Kansas Medical Center, Division of Hematologic Malignancies and Cellular Therapy, Kansas City, KS, United States.
高压氧气 (HBO) 疗法可以改善带血 (UCB) 移植患者的结果. 与标准的UCB移植相比,HBO治疗导致了更快的红细胞 (PRBC) 和血小板独立,并减少了生长因子的使用.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 高压医学的高压医学.
背景情况:
- 带血 (UCB) 移植因干细胞数量低而受到挑战,导致移植延迟和输血需求增加.
- 高压氧 (HBO) 疗法在临床前研究和早期人体试验中已经显示出增强移植和血液计数恢复的潜力.
研究的目的:
- 评估HBO治疗对UCB移植受体输血独立性和生长因子利用的影响.
- 将UCB移植与HBO治疗的结果与历史的UCB移植数据进行比较.
主要方法:
- 15名受试者在HBO治疗后接受了UCB移植,并减少了强度或骨髓缩条件.
- 分析了患者记录,以确定移植后的红细胞和血小板输血需求以及生长因子的使用.
- 结果与同一机构的标准UCB移植接受者的历史队列进行了比较.
主要成果:
- 与标准UCB组相比,接受HBO治疗的患者实现了明显更快的PRBC和血小板独立.
- 到第100天,100%的HBO患者没有接受PRBC和血小板输血,而标准组的比例分别为67.4%和65.1%.
- HBO治疗与连续几天的G-CSF支持较少相关.
结论:
- 在成年UCB移植接受者中,HBO疗法在改善移植和减少输血需求方面表现有前途.
- 这种疗法可以增强UCB移植后的生长因子支持和独立时间 (TTI).
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