暴露于重金属和型肝炎病毒感染:一个横截面研究
Humairat H Rahman1, Weston R Stokey2, Jonah Green3
1New Mexico State University, MSC 3HLS, 1335 International Mall, PO Box 30001, Las Cruces, NM 88003, USA.
概括
肝炎C病毒 (HCV) 感染与更高水平的,和暴露有关. 这项研究强调了环境金属与HCV流行之间的联系,影响公共卫生战略.
科学领域:
- 环境健康 环境健康
- 传染性疾病 传染性疾病
- 毒理学 毒理学 毒理学
背景情况:
- 肝炎C病毒 (HCV) 是一个重要的公共卫生问题,慢性感染率很高.
- 由于工业应用,环境金属暴露非常普遍,难以避免.
研究的目的:
- 调查暴露于特定金属 (Ba,Cd,Co,Mn,Mo,Pb,Sb,Tl,Sn,W) 与HCV感染的流行率之间的联系.
- 在大量成年人群中分析尿液金属含量与HCV状况之间的关系.
主要方法:
- 利用了2013-2020年国家健康和营养检查调查 (NHANES) 的数据.
- 在18,073名参与者 (年龄在20-80岁) 上使用了加权复杂的后勤回归分析,采用了5751个尿样.
主要成果:
- 肝炎病毒感染与尿道 (Co) 水平的增加有积极的关联.
- 在四分位数3和4中,观察到HCV的更高患病率与 (W) 暴露的增加.
- (Mo) 暴露与更高四分位数中HCV阳性几率的增加显著相关.
结论:
- 感染HCV的患病率与环境暴露于,和有关.
- 这些发现强调了环境暴露和疾病结果的关键交叉点.
- 强调在公共卫生研究和传染病干预中考虑环境因素的重要性.
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