在代谢功能障碍相关的脂肪性肝病中,时间限制饮食的有效性和安全性
Joo Hyun Oh1, Eileen L Yoon2, Huiyul Park3
1Department of Gastroenterology, CHA University School of Medicine, Seongnam, Republic of Korea.
Journal of hepatology
|June 21, 2025
概括
时间限制饮食 (TRE) 在患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者中显著减少了肝脂肪. 与卡路里限制相比,TRE提供了可比的减肥和代谢改善,建议它作为一种实际的饮食策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 饮食干预 饮食干预
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与肥胖和胰岛素抵抗有关.
- 时间限制饮食 (TRE) 显示出改善代谢健康标志物的潜力.
- 关于TRE在MASLD患者的疗效的证据有限.
研究的目的:
- 评估TRE对超重/肥胖和MASLD患者的益处.
- 将TRE与卡路里限制 (CR) 和标准护理 (SOC) 进行比较.
- 评估对肝脏肥胖症,身体组成和代谢参数的影响.
主要方法:
- 16周的随机对照试验. 16周的随机对照试验.
- 三个手臂:SOC,CR和TRE (1:1:1的比例).
- 主要终点:通过MRI-质子密度脂肪分数的肝肥.
主要成果:
- 与SOC (0.7%,p<0.001) 相比,TRE显著降低了肝肥胖症 (-25.8%).
- TRE显示肝脏肥胖症的降低与CR (-24.7%) 相似.
- 与SOC相比,TRE导致体重,腰围和身体脂肪量减少得更大,类似于CR.
结论:
- 在MASLD中,TRE有效地降低了肝硬化症.
- 在减肥和代谢改善方面,TRE提供了与CR相似的好处.
- 对于MASLD管理,TRE可能是一个实用的饮食策略.
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