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在长期接触电子烟后,性变态对隔膜肌肉的影响

Ana Beatriz Farias de Souza¹, Pedro Alves Machado-Junior¹, Sirlaine Pio²

¹Laboratory of Experimental Pathophysiology (LAFEx), Department of Biological Sciences and Center of Research in Biological Sciences, Federal University of Ouro Preto (UFOP), 35402-136 Ouro Preto, MG, Brazil.

Toxicology and applied pharmacology

|June 21, 2025

概括

电子烟 (e-cig) 暴露会在老鼠腹膜肌肉中引起炎症和氧化应激,即使在恢复期后也是如此. 雌性小鼠对这些不良健康影响的敏感性更大.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
肺部医学肺部医学

背景情况:

吸烟是全球主要的健康问题,也是慢性阻塞性肺病的主要风险因素.
电子烟 (e-cigs) 是作为传统香烟的替代品销售的.
电子烟气溶,就像香烟烟雾一样,含有与炎症和氧化应激有关的有毒化合物.

研究的目的:

研究传统香烟和电子烟暴露对雄性和雌性小鼠腹膜肌肉的影响.
评估血和隔膜组织中炎症和氧化应激的生物标志物.

主要方法:

雄性和雌性C57BL/6小鼠被分为对照组,常规香烟和电子烟组.
动物暴露了60天,随后是60天的恢复期.
分析了血和隔膜组织的生物化学标记物.

主要成果:

在女性中,电子烟暴露增加了血中的肌酸激酶,IL-6,IL-12和IL-10水平.
隔膜肌肉分析显示,暴露于电子烟的两性人群中,总蛋白质增加,超氧化物转化酶活性降低,触酶活性改变.
炎症标志物 (TNF,IL-6,IL-12) 在两性中都升高,女性的IL-10水平更高.

结论:

电子烟暴露会引起炎症和腹膜氧化应激,即使经过康复期也会持续下去.
雌性小鼠对电子烟暴露的有害影响表现出更高的敏感性.
调查结果强调了与电子烟使用相关的潜在风险,特别是关于呼吸道肌肉健康的风险.

关键词:

隔膜肌肉隔膜肌肉电子烟是一种电子烟.一个女人,一个女人.炎症炎症是一种炎症.男人男人男人男人男人雷多克斯不平衡是什么意思

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