老年人肺移植:年龄是一个禁忌吗?
Mark Shacker1, Andrew Keogan2, Lucas Wang1
1Creighton University School of Medicine, Phoenix, Arizona.
The Annals of thoracic surgery
|June 21, 2025
概括
与年轻患者相比,老年接受者 (65岁以上) 的肺移植结果与短期的年轻患者相似. 晚年显示可接受的长期存活率,仔细的选择改善了结果.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 移植手术 移植手术
背景情况:
- 老年患者接受肺移植的患病率越来越高.
- 需要对接受肺移植的老年人群探索结果.
研究的目的:
- 为了比较年龄较大与年轻患者组的肺移植结果.
- 评估接受者的晚年对短期和长期生存的影响.
主要方法:
- 从2007年4月到2023年3月的双边肺移植记录的回顾性审查.
- 使用单变量和多变量分析对患者特征和结果进行比较.
- 患者分为15-64岁,65-69岁,70-74岁和75-79岁的年龄组.
主要成果:
- 年龄较大的接受者表现出更高的男性性别,白人种族和限制性肺病率.
- 年轻的接受者在移植前更频繁地需要呼吸系统支持.
- 一年生存率在各年龄组 (15-74岁) 中是相似的;中位数的生存率随着年龄的增长而下降.
- 五年生存率从44.5%到58.0%不等,老年人群的生存率略低一些.
结论:
- 肺移植的短期结果在65岁及以上的接受者和年轻患者之间是相似的.
- 领先的接受者年龄与不太有利但可以接受的长期生存有关.
- 仔细选择老年肺移植接受者可以改善外科手术后的结果和短期生存.
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