生物降解纤维素基凝辅助瘤向纳米颗粒自我增强的铁和DOX诱导的化疗
Zhiyuan Niu1, Shengbo Wu2, He Ding3
1The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, PR China; Department of Medical Ultrasound, Henan Provincial People's Hospital, School of Medicine, Henan University, Zhengzhou, Henan 450003, PR China.
这项研究引入了一种充满纳米粒子的注射凝,用于向癌症治疗. 这种新的方法将化疗与铁灭症结合起来,以提高治疗效率,并在小鼠中实现100%的存活率.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 静脉注射化疗会引起全身毒性.
- 局部瘤治疗需要有针对性的药物输送.
- 铁化是一种新兴的癌症治疗策略.
研究的目的:
- 开发一种可注射,可生物降解的凝,用于局部瘤治疗.
- 将多克索鲁比 (DOX) 化疗与铁死结合起来.
- 使用DOX和铁基纳米粒子 (FeP) 创建一种自我增强疗法.
主要方法:
- 制造含有DOX和FeP的氨酸 (HA) 修饰的纳米粒子 (DOX&FeP-HA).
- 在纤维素基凝支架内封装DOX&FeP-HA纳米粒子.
- 在实验室中描述纳米粒子释放动力学和TME触发的降解.
- 在4T1瘤携带小鼠体内治疗疗效的体内评估.
主要成果:
- DOX&FeP-HA纳米颗粒证明了CD44的生物向,稳定性和持续的药物释放 (在48小时内约80%).
- 结合疗法诱导了亡,产生了活性氧物种 (ROS),消耗了谷氨 (GSH),并减少了GPX4的表达,放大了铁亡.
- 在30天内,DOX&FeP-HA@gel治疗导致4T1瘤携带小鼠的100%存活率.
结论:
- 一种携带多功能纳米颗粒的局部注射凝为局部瘤治疗提供了一种有前途的方法.
- 该DOX&FeP-HA@gel系统有效地结合化疗和ferroptosis,以增强抗瘤效果.
- 这一策略显示了癌症治疗中临床应用的巨大潜力.
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