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用MXene修饰的PMMA/奇托桑复合物电子皮肤支架:生物电子和抗菌评估

Berfin Gürbüz¹, Fatih Ciftci², Ali Can Özarslan³

¹Department of Biomedical Engineering, Fatih Sultan Mehmet Vakıf University, Istanbul, Turkey; Biomedical Electronic Design Application and Research Centre (BETAM), Fatih Sultan Mehmet Vakıf University, Istanbul, Turkey.

International journal of biological macromolecules

|June 21, 2025

概括

这项研究开发了先进的PMMA-MXene-chitosan (CS) 电子皮肤支架,用于伤口愈合. 这些多功能支架显示出优越的机械,电气和广泛的抗微生物特性,用于下一代可穿戴设备.

科学领域:

组织工程是组织工程.
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

电子皮肤 (e-skin) 贴片被用于组织工程中的可穿戴伤口带,以增强愈合.
开发具有改进性能的多功能电子皮肤支架对于先进的生物医学应用至关重要.

研究的目的:

使用PMMA,MXene和奇托 (CS) 的电纳米纤维复合材料制造和表征多功能电子皮肤支架.
评估开发的PMMA-MXene-CS复合材料电子皮肤支架的机械,电气,热和抗菌性能,用于组织工程应用.

主要方法:

用PMMA,MXene和CS进行电,以创建复合纳米纤维支架.
脚手架形态的表征,孔隙性,机械强度,介电性质,导热性,以及对各种病原体的抗菌活性.

主要成果:

PMMA-MXene-CS支架表现出统一的纤维形态,高孔度 (>85%) 和增强的机械性能 (拉伸强度13 MPa,Young的模量0.38 GPa,在断裂时延伸200%).
观察到优良的电气性能,包括最小损失触点 (<0.05),内置电位 (1.19 V) 和低泄漏电流,表明信号保真度高.
异常广泛的抗微生物疗效被证明,与高抑制率对大肠杆菌 (95%),黄金葡萄球菌 (92%),白 Candida (99%),和显著的抑制区域对肺炎菌株和单细胞菌株李斯特菌.

结论:

复合物PMMA-MXene-CS电子皮革支架具有机械强度,电性能和强大的抗菌活性的有希望的组合.
这些多功能支架非常适合在组织工程和伤口管理中用于下一代灵活,耐用和先进的电子皮肤应用.

关键词:

抗菌剂抗菌剂抗菌剂基托桑是一种酸盐.复合材料是一种复合材料.电子皮革脚手架的脚手架.这就是MXene MXene.这就是PMMA的PMMA.

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