帕金森病的低连接模式与纯粹的冷漠:一个动态的功能连接视角
Yan Zhi1, Kaidong Chen2, Yiping You3
1Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China; Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Neurobiology of disease
|June 21, 2025
概括
帕金森病 (PD) 中的冷漠与长期低脑网络连接性有关. 具体来说,在预先设置模式网络 (DMN) 中, precuneus 和 SFGmed 之间的连接性降低可能会导致 PD 患者的冷漠.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 脑部成像 脑部成像
背景情况:
- 漠不关心是帕金森病 (PD) 的一个常见的非运动症状.
- 了解PD中无动于衷的脑网络动态至关重要.
- 以前的研究还没有完全阐明PD和纯无视 (PD-PA) 患者的动态功能网络连接 (dFNC).
研究的目的:
- 为了研究与帕金森病中冷漠相关的动态大脑网络变化.
- 使用dFNC分析探索PD-PA患者大脑中的功能连接模式.
主要方法:
- 使用动态功能网络连接 (dFNC) 分析.
- 研究了30名PD-PA患者,37名PD但不完全冷漠的患者 (PD-NPA) 和37名健康对照 (HC).
- 确定了七个大脑网络,配置成四个不同的状态.
主要成果:
- 与PD-NPA患者相比,PD-PA患者在低连接状态 (状态1) 中的平均停留时间较长.
- 在状态1中的平均停留时间与PD-PA患者的冷漠度严重程度正相关.
- 在状态1中,在PD-PA患者的默认模式网络 (DMN) 中观察到网络内部功能连接 (FC) 的下降,特别是涉及左侧前骨和左侧中侧上额回 (SFGmed).
结论:
- 患PD的冷漠可能源于大脑网络中长时间的低连接性.
- 信息传输受损,特别是DMN内的前和SFGmed之间的断开,是PD无动于衷的一个关键机制.
相关概念视频
01:15Parkinson's Disease: Overview
722
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
722
01:24Parkinson's Disease: Treatment
391
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
391
01:37Neural Regulation
40.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.4K
01:30Negative and Cognitive Symptoms of Schizophrenia
129
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
129
01:13Functional Brain Systems: Reticular Formation
2.7K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.7K
01:27Depressive Disorders: Etiology
173
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
173