在HeartMate 3左心室辅助器件支持中性别差异和结果:来自J-MACS注册表的结果
Makiko Nakamura1, Teruhiko Imamura1, Masaki Nakagaito1
1Second Department of Internal Medicine, University of Toyama, Toyama, Japan.
Journal of cardiology
|June 21, 2025
概括
接受HeartMate 3左心室辅助装置 (LVAD) 的女性住院时间更长,因出血而重新入院的比例更高,但整体存活率与男性相似. 需要进一步研究LVAD植入后妇女的出血风险.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 临床结果 临床结果
背景情况:
- 之前的研究表明,左心室辅助装置 (LVAD) 植入后女性的结果较差,可能是由于身体表面积较小.
- 当代LVADHeartMate 3在较小体型的日本人群中的预后影响尚不清楚.
研究的目的:
- 为了研究HeartMate 3 LVAD植入在晚期心力衰竭患者中的性别特异性结果.
- 为了比较男性和女性之间的死亡率,功能类别和不良事件.
主要方法:
- 在2019-2023年期间从日本机械辅助循环支持登记处接受HeartMate 3 LVAD的465名患者的分析.
- 累积死亡率,纽约心脏协会 (NYHA) 功能类和性别之间的再住院事件的回顾性比较.
主要成果:
- 女性的中位数住院时间较长 (85天与75天).
- 在964天的中位随访期间,性别之间没有观察到累积死亡率的显著差异.
- 由于严重出血,女性的再住院风险更高 (调整后的危险比:3.343).
结论:
- 植入HeartMate 3并没有影响性别之间的整体死亡率.
- 女性经历了需要住院治疗的重大出血事件的风险增加.
- 需要进一步的研究,以了解女性出血再入院增加背后的机制.
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