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Updated: Jul 26, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
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Published on: December 29, 2014

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BACE1和内源性Aβ:环境丰富中介行为标记中的新型PRP复合物

Medha Kaushik1, Sharon Jacob1, Pinky1

  • 1Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.

Neuroscience
|June 21, 2025
PubMed
概括

这项研究表明,抑制β位粉样蛋白前体蛋白分裂酶1 (BACE1) 有助于在新型物体识别任务中巩固长期记忆. 这突出了BACE1和β-粉样蛋白作为记忆形成的关键参与者.

关键词:
长期记忆 长期记忆 长期记忆记忆的巩固 记忆的巩固新奇的曝光 新奇的曝光在 PKMζζ PKMζζ与可塑性相关的蛋白质

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...