在精神分裂症和双相情感障碍患者的环状回路内,细胞类型特异性减少了内部神经元基因表达
David M Krolewski1, Huzefa Khalil2, Maria Waselus2
1Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA. dkrolews@umich.edu.
Schizophrenia (Heidelberg, Germany)
|June 21, 2025
概括
精神分裂症和双相情感障碍有共同的认知缺陷,这些缺陷与 cingulate gyrus GABA 内神经元有关. 对两种疾病的基因表达分析揭示了这些大脑区域的独特和重叠的分子特征.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 分子生物学分子生物学
背景情况:
- 精神分裂症 (SZ) 和双相情感障碍 (BP) 呈现重叠的神经认知缺陷.
- 带带回形中受损的GABA活性内神经元与SZ和BP的认知障碍有关.
研究的目的:
- 研究特定带带状回形子区域的基因表达特征和SZ和BP中的内部神经元类型.
- 为了确定与这些疾病相关的独特和共享的转录性改变.
主要方法:
- 放射性 in situ 杂交被用来检查基因表达.
- 在带状回形的布罗德曼区域 (BA) 中分析了内神经元细胞类型的特定标记物 (GAD67,PV,SST,VIP).
- 分析的特定子区域包括前半皮质 (aMCC),后皮质 (RSC) 和外皮质 (ESC).
主要成果:
- 在高血压患者的aMCC (BA24c') 中观察到减少的GAD67mRNA.
- 在SZ受试者的aMCC中发现了减少的PV和VIPmRNA.
- 减少PV表达在RSC和ESC的SZ和BP受试者中都是常见的.
结论:
- 独特的和共享的基因表达特征存在于SZ和BP的环状回形子区域和细胞类型中.
- 在SZ和BP中分离的aMCC基因表达表明疾病特异性的转录变化影响了错误检测和突出等功能.
- 在RSC/ESC中共享的转录变化可能与默认模式网络中对视觉空间记忆和注意力的共同影响有关.
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