选择元素在非处方止痛药中的度水平:使用诱导合等离子体 - 质谱仪对不同来源进行比较研究
Adnan M Massadeh1, Alaa H Abu Hatab2
1Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan. massadeh@just.edu.jo.
Biological trace element research
|June 21, 2025
概括
无处方止痛药中的重金属污染,如青,二二和布洛芬是全球关注的问题. 虽然大多数样品达到安全限值,但一些约旦,阿联,沙特和瑞士的止痛药超过了允许的和含量.
科学领域:
- 药品分析 药品分析
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 药品中的重金属污染是一个重要的国际问题.
- 止痛药,包括白醇,迪克洛菲纳克和布洛芬,可能会造成重金属中毒的风险.
- 由于潜在的不良健康影响,确保药品安全至关重要.
研究的目的:
- 为了评估在非处方止痛药中的 (Pb), (Cd), (As), (Cr),铜 (Cu) 和 (Ni) 的元素度水平.
- 将测量的元素度与美国药典 (USP) 设定的允许极限进行比较.
- 评估不同国家广泛使用的止痛药中重金属污染的潜在风险.
主要方法:
- 使用诱导合等离子体质谱法 (ICP-MS) 来量化元素度.
- 分析了来自约旦,阿联,沙特阿拉伯和瑞士的32个非处方止痛药样本 (青,二二,布洛芬).
- 统计分析,包括单向ANOVA,用于比较不同药物类型和国家的基本水平.
主要成果:
- ,和在偏醇样本中最丰富;,和铜在迪克洛芬雅克样本中最多.
- 大多数样本符合USP允许的限值,但一些约旦和阿联的甲醇样本超过了和的限值.
- 一些约旦,沙特和瑞士的迪克洛芬加和布洛芬样本也显示含量超过了USP限制.
结论:
- 虽然大多数分析的非处方止痛药都在安全的基本限度内,但在某些品牌和国家确诊了特定的和超值情况.
- 这些发现强调了对药品进行严格的质量控制和监测的持续需求,以防止重金属暴露.
- 持续警和遵守药典标准对于保护公众健康免受受污染的药物的保护至关重要.
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