膀癌化学放射治疗对先前存在的水缩和新水缩的发展的影响
Marinka J Remmelink1,2, Nader El Awadly3, Berber Arbeel-Weening4
1VUmc Department of Urology , Amsterdam University Medical Center, University of Amsterdam, Boelelaan 1117, Amsterdam, 1081HV, The Netherlands. m.j.remmelink@amsterdamumc.nl.
Radiation oncology (London, England)
|June 21, 2025
概括
大多数患有肌肉侵入性膀癌 (MIBC) 和先前存在的水缩症的患者在化疗放射治疗 (CRT) 后经历了持续的水缩症. 大约20%没有水性的MIBC患者在CRT后发展到水性,往往需要干预.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
背景情况:
- 激进囊切除术是肌肉侵袭性膀癌 (MIBC) 与水溶解的标准.
- 关于化疗辐射疗法 (CRT) 对MIBC患者先前存在的或新发的水缩症的影响的数据有限.
- 这项研究调查了MIBC的CRT后的水缩发病率,原因和管理.
研究的目的:
- 评估肌肉侵入性膀癌 (MIBC) 患者化学放射治疗 (CRT) 之前和之后的水性缩的发生率.
- 为了确定在这个群体中导致水缩的病因因素.
- 评估在接受CRT的MIBC患者中水性的管理策略.
主要方法:
- 在2014年至2022年期间,对146名肌肉侵入性膀癌 (MIBC) 患者进行了回顾性队列研究,这些患者接受了化疗放射治疗 (CRT).
- 包括具有特定标准的患者 (例如,尿道泌尿道癌,T1阶段与全膀辐射)
- 在成像上定义为骨和/或尿道扩张的水性,是主要的结局.
主要成果:
- 在146名患者中,有27名患者有先前存在的水;74%的CRT后持续存在,44%需要排水.
- 在没有先前存在的水性的患者中,有21%的患者在CRT后出现了水性,其中52%的患者需要排水.
- 瘤是先前存在的水缩 (93%) 和CRT后的水缩的主要原因 (先前存在的水缩患者中有22%,没有水缩患者中有11/25).
结论:
- 经过CRT后,先前存在的水解在约75%的MIBC患者中持续存在.
- 大约20%的MIBC患者没有先前的水性化,在CRT后发展到CRT,大约一半需要干预.
- 调查结果有助于就CRT后的结果向MIBC患者提供咨询.
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