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Updated: Sep 8, 2025

Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish
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由RIPK1/3依赖的线粒体DNA释放调节的AIM2激活驱动Aβ1-40-诱导视网膜色素表皮损伤

Xiaoxu Huang1,2,3, Tongqi Li1,2,3, Guanran Zhang1,2,3

  • 1Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cell communication and signaling : CCS
|June 21, 2025
PubMed
概括

氨基酸β (Aβ) 通过AIM2炎症酶途径触发视网膜色素表皮 (RPE) 损伤. 抑制RIPK1/RIPK3可减少炎症和线粒体DNA释放,提供潜在的AMD治疗方法.

关键词:
在AIM2中,AIM2是AIM2.与年龄相关的黄斑变性.粉样蛋白 β 是一种粉样蛋白.在RIPK1中使用.在RIPK3中使用RIPK3.视网膜色素上皮细胞 视网膜色素上皮细胞

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