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作为多目标抗阿尔茨海默氏症剂的皮拉佐洛皮里丁含化合物:合成,生物评估和在研究中

Omnia M Waly1,2, Selwan M El-Sayed1,3, Mariam A Ghaly1

  • 1Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Archiv der Pharmazie
|June 22, 2025
PubMed
概括

新的基于pyrazolopyridine的多目标定向联结体 (MTDLs) 通过抑制关键的病理途径,对阿尔茨海默病 (AD) 治疗有希望. 化合物15和23显示出显著的活性和安全性,表明潜在的治疗应用.

关键词:
抑制了Aβ1-42聚合的发生.在hAChE抑制过程中.hBuChE 的抑制作用.抑制了hGSK3β的发生.皮拉佐洛皮里丁的合成方法的聚合抑制 的聚合抑制

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