用手术前放射治疗治疗的状脂肉瘤的放射和病理反应
Robert W Gao1, Judith As Jebastin2, Doris E Wenger3
11Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Radiology and oncology
|June 22, 2025
概括
手术前的放射治疗显著降低了myxoid liposarcoma (MLPS) 瘤体积和最大尺寸. 适应性放射治疗规划可以通过减少目标体积来最大限度地减少与治疗相关的副作用.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 医疗成像医学成像
背景情况:
- 状脂类肉瘤 (MLPS) 是一种软组织肉瘤.
- 手术前放射治疗 (RT) 是MLPS的一种治疗方式.
- 评估对RT的体积反应对于治疗优化至关重要.
研究的目的:
- 以回顾评估MLPS对手术前RT的体积反应.
- 为了确定与体积反应相关的疾病和治疗特征.
主要方法:
- 对20名MLPS患者进行了回顾性分析,这些患者接受了手术前RT (2013-2021年).
- 瘤体积和最大维度在RT期间使用圆束计算断层扫描 (CBCT) 进行评估.
- 在RT前后的磁共振成像 (MRI) 评估了放射特征.
- 对病理学特征进行了手术病理学的审查.
主要成果:
- 在RT期间,中位瘤体积减少了37%,最大尺寸减少了10%.
- 所有可评估的瘤都显示体积下降.
- 大多数患者经历了减少的内和周胀.
- 16名患者表现出广泛的病理反应.
- 在放射/病理特征和体积变化之间没有发现显著的关联.
- 在3年内,本地失效率为9%.
结论:
- 手术前的RT导致MLPS的瘤大小显著减少.
- 适应性RT规划可能会减少目标体积和RT相关的发病率.
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