在儿科发病的多发性硬化症中高血压的患病率和与疾病进程的关联:一个病例对照研究
Darina Dinov1, Alexia Richie2, Brenna Kent3
1Division of Child Neurology, Department of Neurology, Children's Hospital of Richmond, VCU Health System, Richmond, VA, USA.
Multiple sclerosis and related disorders
|June 22, 2025
概括
儿科发病多发性硬化症 (MS) 与高血压 (HTN) 的更高患病率有关. 在患有多发性硬化症的年轻人中,这种并发性疾病可能会增加炎症病变发展的风险.
科学领域:
- 神经学 神经学
- 儿科 儿科 儿科
- 心脏病学 心脏病学
背景情况:
- 患有多发性硬化症 (MS) 的成年人表现出高血压 (HTN) 率的增加,与更大的残疾相关.
- 儿科发病性MS (POMS) 中HTN的患病率和影响在很大程度上仍未被描述.
研究的目的:
- 确定POMS患者中HTN的流行率.
- 调查HTN与POMS中的疾病活性之间的关联.
主要方法:
- 一项多中心的回顾性研究将POMS (iwPOMS) 患者的血压 (BP) 与匹配的对照进行了比较.
- 高血压的定义是使用美国儿科学会的指导方针,基于至少三次高血压记录.
- 通过中性粒细胞与淋巴细胞的比率和MRI上新的T2高强度病变来评估疾病活性.
主要成果:
- 该研究包括96个iwPOMS和96个对照组,显示iwPOMS中HTN患病率 (22%) 与对照组 (6%) 相比显著更高.
- iwPOMS在基线和12个月和24个月的纵向表现出较高的缩血压.
- 在24个月后,在具有HTN的iwPOMS中观察到新的T2高强度病变的更高发病率.
结论:
- 与匹配的对照人群相比,患有POMS的人患高血压的患病率更高.
- 在患有多发性硬化症的年轻人中,HTN的同时发生可能会增加患有炎症病变的风险.
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