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在美国患者中乳头甲状腺癌的趋势 年龄在10-19岁的青少年:A SEER数据库分析分析
J B Eyring1, Christopher Nielson2, Michelle Meder3
1Spencer Fox Eccles School of Medicine, University of Utah, USA; University of Utah Department of Otolaryngology Head & Neck Surgery, USA.
在15-19岁的女性中,儿科乳头甲状腺癌的发病率在2012年之前一直在上升,然后下降. 持续监测对于理解这些儿童癌症趋势的变化至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 流行病学 流行病学
- 癌症趋势 癌症趋势
背景情况:
- 儿科乳头甲状腺癌 (PTC) 发病率表现出复杂的趋势.
- 了解人口和时间变化对于公共卫生倡议至关重要.
研究的目的:
- 评估从1975年到2021年的儿科PTC发病率趋势.
- 通过分析人口因素来确定这些趋势的潜在驱动因素.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库中对儿科PTC病例 (10-19岁) 的回顾性分析.
- 加入点回归分析以确定显著的趋势变化,按性别,年龄,种族/种族,收入和地理分层.
- 年龄调整到2020年美国标准人口和收入的通胀调整到2022年美元.
主要成果:
- 该研究分析了2117例儿科PTC病例,主要是15-19岁 (76.3%) 的女性 (79.5%).
- 15-19岁女性的发病率从2006-2012年大幅增加 (每年9.61%),但从2012-2021年减少 (每年3.60%).
- 在收入和地理水平上都出现了下降,但种族差异仍然存在,西班牙裔女性的比例上升,尽管非西班牙裔白人女性的比例下降.
结论:
- 自2012年以来,15-18岁女性的儿科PTC发病率大幅下降,扭转了之前的上升趋势.
- 需要进一步的研究来阐明这种下降的原因,包括诊断实践的潜在转变或暴露于危险因素.
- 持续的监测对于了解不断发展的儿科癌症流行病学至关重要.
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