![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
基于氨酸的超分子合组件用于酶选择性相互作用和增强光动力学疗法
Xiaohuan Sun1, Yuhe Yuan1, Yan Lu1
1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Journal of colloid and interface science
|June 22, 2025
概括
由D/L-氨酸和氨酸制成的基拉尔纳米颗粒显示,D-enantiomer显著增强了癌症治疗. 这种奇拉性转移可以促进药物吸收和光动力治疗的疗效.
科学领域:
- 超分子化学 超分子化学
- 纳米医学是一种纳米医学.
- 治疗药物中的奇拉性
背景情况:
- 超分子合组件主要被研究为药物载体,因为它们与生物系统的反选择性相互作用.
- 目前的方法可能会损害依赖于性的治疗疗效,并忽视性在纳米医学中的更广泛意义.
研究的目的:
- 通过使用D/L-氨酸 (Arg) 和 meso-tetra(4-carboxyphenyl) 氨酸 (TCPP) 来构建超分子性纳米粒子.
- 调查这些组件中的Arg到TCPP的性转移.
- 评估对细胞吸收和光动力学抗瘤功能的反反子特异相互作用的影响.
主要方法:
- D/L-氨酸 (Arg) 和氨酸 (TCPP) 的自组合,形成超分子性纳米粒子.
- 从Arg到TCPP的奇拉性转移分析.
- 通过卡韦林依赖性内细胞分解评估细胞吸收效率.
- 对依赖异构体的活性氧物种 (ROS) 生产和光动力学抗瘤疗效的评估.
主要成果:
- 通过从D/L-Arg的奇拉性转移,在超分子组合内实现了TCPP的直接奇拉性诱导.
- 与L-Arg-TCPP相比,D-Arg-TCPP纳米颗粒的细胞吸收效率高1.5倍,其媒介是enantioselective蛋白相互作用和caveolin-dependent endocytosis.
- 与L-Arg-TCPP相比,D-Arg-TCPP的光动力学抗瘤疗效是1.9倍高,这归因于依赖于反原体的ROS生成.
结论:
- 这项研究阐明了基于氨酸的超分子组件中依赖于性性行为的机制.
- 研究结果强调了性在优化纳米医药疗效方面发挥的关键作用.
- 这项工作提出了一种新的策略,用于增强性介导的癌症治疗.
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
相关概念视频
02:05Prochirality
4.0K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.0K
01:26Photochemical Electrocyclic Reactions: Stereochemistry
1.9K
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
1.9K
02:17Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
3.4K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.4K
02:52Stereoisomerism
12.4K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
12.4K
02:30Chirality in Nature
14.0K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
14.0K
02:30Chirality at Nitrogen, Phosphorus, and Sulfur
6.0K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
6.0K