计算引导的多功能纳米平台,用于增强口服输送和向治疗Helicobacter pylori,使用草本生物活性物质
Chuqiu Zhang1, Haobo Chen2, Yuanjing Zou2
1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, PR China; Institute for Health Innovation & Technology, National University of Singapore, Singapore, 117599, Singapore.
一个新的纳米平台有效地提供草药化合物来对抗Helicobacter pylori (H. pylori) 感染. 这种方法增强了药物输送,减少了细菌负载,并支持健康的肠道微生物群.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
- 计算化学计算化学
背景情况:
- 植物生物活性化合物显示出消除Helicobacter pylori (H. pylori) 的潜力.
- 口服生物可用性较差和目标部位积累不足限制了草药的临床使用.
- 需要先进的药物输送系统来改善H. pylori根除疗法.
研究的目的:
- 开发一个以计算为导向的多功能纳米平台,用于向的H. pylori治疗.
- 将tanshinone I (Tan_I) 封装到一个二化fucoidan-polydopamine (PDA-FuSH) 纳米载体中.
- 在体外和体内评估T@PDA-FuSH纳米平台的有效性.
主要方法:
- 利用密度函数理论 (DFT) 和分子动力学 (MD) 模拟用于计算设计.
- 制造了一种硫化福可伊丹-多多多巴胺 (PDA-FuSH) 纳米载体,用于tanshinone I (Tan_I) 封装.
- 评估了纳米平台的稳定性,药物载荷,粘膜粘合和对H. pylori菌株的杀菌活性.
- 在H. pylori感染的小鼠模型中进行了体内研究.
主要成果:
- T@PDA-FuSH纳米平台表现出卓越的稳定性,高药物负载和强大的粘膜粘合.
- 已证明对标准和耐药的H. pylori有强大的杀菌作用.
- 在体内,T@PDA-FuSH显著降低了H. pylori的负担,炎症,并改善了胃粘膜的完整性.
- 维护胃微生物群的稳态,增加有益的益生菌,如乳酸菌和Bifidobacterium.
结论:
- 计算引导的方法成功地创建了一个优化的纳米平台,用于草药生物活性输送.
- T@PDA-FuSH为H. pylori感染提供了增强的治疗疗效,并改善了口服生物可用性.
- 这一战略代表了开发有效治疗H. pylori的有希望的进步.
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