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用益生菌嵌入口腔健康的聚合物薄膜:开发,表征和治疗潜力

Charlotte Eckermann¹, Christof Johannes Klein¹, Florian Schäfer²

¹Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbrücken 66123, Germany; PharmaScienceHub (PSH), Saarbrücken 66123, Germany.

Colloids and surfaces. B, Biointerfaces

|June 22, 2025

概括

新的益生菌膜增强了有益的口腔细菌 (Lactobacillus rhamnosus,Lactobacillus reuteri) 并减少了有害的细菌. 这种粘膜传递系统通过调节口腔微生物群来预防口腔疾病有望.

科学领域:

微生物学微生物学
生物材料科学生物材料科学
牙科研究牙科研究

背景情况:

口腔微生物组对平衡至关重要;不平衡与牙周炎有关.
益生菌如Lactobacillus rhamnosus和Lactobacillus reuteri显示出对口腔健康的潜在影响.
在口腔环境中的益生菌生存和坚持存在挑战.

研究的目的:

开发和评估粘膜聚合物薄膜,以有效地在当地输送口服益生菌.
评估微囊益生菌的稳定性和口内传递能力.

主要方法:

使用喷雾干燥的方式微封装Lactobacillus rhamnosus和Lactobacillus reuteri.
在基基甲基纤维素-聚乙烯醇 (HPMC-PVA) 和泡聚乙烯醇 (PVA) 薄膜中加入微封装益生菌.
薄膜特性 (细菌活力,机械,粘粘性) 的表征和使用共聚焦成像的体内概念验证研究.

主要成果:

微封装保持了高的细菌活力.
片表现出良好的机械强度和显著的粘膜粘合性.
在体内研究表明,杆状乳酸菌的粘附性增加,菌减少.
泡PVA薄膜显示了与质相关的微生物群的最显著调节.

结论:

含有益生菌的薄膜为细菌稳定和有效的口服输送提供了可行的策略.
这种粘膜系统促进有益细菌的殖民,并减少潜在的致病细菌.
这种方法代表了一种有希望的基于微生物组的口腔疾病预防策略,需要进一步的临床研究.

关键词:

牛乳杆菌reuteri 牛乳杆菌reuteri 是一个乳杆菌 rhamnosusus 的乳杆菌.微封装是一种微封装.粘粘性聚合物薄膜是一种粘粘性聚合物薄膜.口腔微生物组是口腔的微生物组.牙周病是指牙周病的发生.

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