对双相情感的心理干预的试验中使用酒精:系统性审查和元分析
Lauren Halsall1, Steven Jones2, Zoe Swithenbank2
1Spectrum Centre for Mental Health Research, Division of Health Research, Lancaster University, Lancaster LA1 4YW, United Kingdom; Centre for Health Informatics, Computing, and Statistics, Lancaster Medical School, Lancaster University, Lancaster LA1 4YW, United Kingdom.
Journal of affective disorders
|June 22, 2025
概括
对双相情感障碍 (BD) 的心理干预试验通常不包括患有酒精使用障碍 (AUD) 的个人. 然而,研究结果显示,这些排除不会影响干预的有效性,这表明需要对同时出现的疾病进行包容性试验.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 成 药物 药物 药物 药物
背景情况:
- 临床指南主张在双极性障碍 (BD) 中进行心理干预.
- 双极性障碍 (BD) 经常与酒精使用障碍 (AUD) 一起发生.
- 关于将AUD患者排除在BD干预试验之外及其对疗效的影响的了解有限.
研究的目的:
- 在BD的心理干预试验中确定与酒精有关的排斥标准的频率.
- 评估是否排除AUD个体会影响BD心理干预的有效性.
- 评估这些试验中随访时的酒精使用量测量.
主要方法:
- 随机对照试验 (RCT) 对 BD 的心理干预进行系统审查.
- 对报告酒精相关排斥标准的试验比例的分析.
- 随机效应元分析,以比较试验之间的干预疗效,包括和排除患有AUD的个体.
主要成果:
- 在92项已识别的试验中,33.7%报告了与酒精有关的排除标准.
- 只有3.3%的试验在随访时测量了酒精使用量.
- 在包括或排除AUD个体的试验之间,没有发现对抑郁或躁狂症状的干预疗效有显著差异.
结论:
- 在BD心理干预试验中,与酒精有关的排斥很普遍.
- 排除患有AUD的个体似乎不会影响这些干预措施的有效性.
- 干预研究应包括患有AUD的个体,以便对同时出现的疾病进行基于证据的治疗评估.
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