在体外,12种挪威药用植物的抗炎特性
Andrea Angelov Eltvik1, Marit Inngjerdingen2, Helle Wangensteen1
1Section for Pharmaceutical Chemistry, Department of Pharmacy, University of Oslo, Oslo, Norway.
Journal of ethnopharmacology
|June 22, 2025
概括
挪威的药用植物显示出抗炎作用的潜力. 马特里卡里亚 discoidea 和 Alnus incana 显示出显著的生物活性,并有望开发新的抗炎药物.
科学领域:
- 民族植物学和植物化学.
- 药理学和药物发现
背景情况:
- 类风湿性关节炎等炎症性疾病对健康构成重大挑战.
- 传统的挪威药用植物为新型抗炎药物提供了潜在的来源.
研究的目的:
- 探索研究不足的挪威药用植物的抗炎性质.
- 为了进一步开发药物,识别富含化合物的植物.
主要方法:
- 历史民族医学记录的系统文献综述.
- 提取和植物化学分析 (1H NMR,HPLC-DAD) 12种选定的植物.
- 在体外测定氧化 (NO),TNF-α抑制和Caco-2细胞屏障保护.
主要成果:
- 一些植物,包括Matricaria discoidea和Alnus incana,表现出中度至高的抗炎生物活性.
- 二甲提取物在抑制NO和TNF-α方面有效;乙醇提取物保护了肠道屏障的完整性.
- M. discoidea和A. incana表现出一致的高生物活性和高比例的化合物.
结论:
- 阿尔努斯·因卡纳和马特里卡利亚·迪斯科迪亚是新型抗炎药物发现的有希望的候选人.
- 进一步的研究将专注于从这两种植物中分离和表征化合物.
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