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Updated: Sep 18, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Published on: September 20, 2017

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通过结晶学障碍提高溶解度:使Peposertib首次在人体上进行试验

Michael Lange1, Clemens Kühn1, Anita Nair1

  • 1Merck Healthcare KGaA, Darmstadt, Germany.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|June 22, 2025
PubMed
概括

一种新的结晶学上无序的固态形式的peposertib (A2D) 在体外显著改善了性能,使得临床试验更快. 这种超稳定形式提供了高稳定性,克服了与无形材料相关的挑战.

关键词:
晶体工程 晶体工程低溶性的药物 低溶性的药物多态性多态性多态性可溶性 可溶性 溶性

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