构建和稳定性评价的新型阿马多里类型的德克斯-素酸-Ca2+输送系统
Ang Gao1, Xinru Han1, Pengyu Liu1
1College of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
International journal of biological macromolecules
|June 22, 2025
概括
一种新型的德克斯-氨酸 (DEX-CPP) 输送系统通过防止消化过程中的沉来增强的吸收. 这种稳定的系统在细胞模型中提高了的生物可用性和吸收效率.
科学领域:
- 营养科学 营养科学
- 生物材料科学 生物材料科学
- 食品化学 食品化学
背景情况:
- 饮食中的的生物可用性受到食物成分的胃肠道沉的限制.
- 在消化过程中形成不溶性盐,减少吸收.
- 需要新的交付系统来克服这些相互作用.
研究的目的:
- 开发一种高效,稳定的阿马多里类型的德克斯-素-脂 (DEX-CPP-Ca2+) 输送系统.
- 为了优化结合能力的条件.
- 为了评估系统的稳定性和输送效率.
主要方法:
- 使用素 (CPP) 和 (DEX) 构建了一个DEX-CPP-Ca2+复合体.
- 优化了CPP:DEX比率,pH值和加热条件,以实现最大的结合.
- 评估释放,酸盐沉抑制和Caco-2细胞吸收.
- 在各种pH值,温度,糖和NaCl度下评估系统稳定性.
主要成果:
- 最佳结合能力 (15.39 mg/g) 在CPP:DEX比为1:3,pH值为8.0,温度为90°C,持续3小时的条件下实现.
- 在体外消化过程中,DEX-CPP-Ca2+系统抑制了酸盐沉,并确保持续释放.
- 在Caco-2细胞模型中观察到提高吸收效率.
- 该系统在广泛的pH值,温度和溶液度范围内表现出异常稳定性.
结论:
- 开发的DEX-CPP-Ca2+系统有效地克服了食物干扰饮食的吸收.
- 这种新型的输送系统为改善的生物可用性提供了一个有希望的策略.
- 该系统的稳定性和有效性支持其在功能性食品中的潜在应用.
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