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通过巨细胞表型调节,对抗肝癌的Polygonatum sibiricum多糖的免疫调节功能和抗癌作用

Maodong Leng¹, Huiqin Jiang², Haiyan Lan³

¹Department of Clinical Laboratory, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China; Department of Clinical Laboratory, Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou 450000, PR China.

International journal of biological macromolecules

|June 22, 2025

概括

聚糖 (PSP) 调节瘤相关巨细胞 (TAMs) 从M2到M1表型,抑制肝癌. 这通过TLR4介导的MyD88依赖途径发生,提供了一种新的癌症治疗策略.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
在瘤学瘤学.

背景情况:

传统中医药中的多糖类具有免疫调节作用.
聚糖 (PSP) 显示出调节瘤微环境的潜力.
与瘤相关的巨细胞 (TAMs) 在癌症进展和免疫规避中发挥着关键作用.

研究的目的:

调查PSP的免疫调节和抗癌作用.
阐明PSP对TAMs作用的基础分子机制.
在肝癌模型中评估PSP的疗效.

主要方法:

在体外巨细胞极化试验.
对TLR4介导的MyD88依赖信号通路的分析.
在体内研究使用肝癌小鼠模型.
免疫组织化学和免疫光测试用于评估TAM表型.

主要成果:

在体外,PSP有效地将M2 TAM转移到M1表型中.
PSP的免疫调节作用是由TLR4-MyD88通路调节的.
在体内,PSP在肝癌中显示出显著的瘤抑制作用.
在瘤组织中,PSP治疗增加了CD86+TAM,降低了CD206+TAM.

结论:

通过将TAM重编程为M1表型,PSP具有免疫调节和抗癌作用.
通过TLR4介导的MyD88依赖途径对PSP的作用机制至关重要.
在肝癌治疗中,PSP是一个有前途的治疗策略.

关键词:

免疫调节功能免疫调节功能巨细胞的现象型这是一种Polygonatum sibiricum多糖化合物.

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