雷姆迪西维尔和COVID-19住院治疗后长期多系统性后果的风险
Liang En Wee1, Jue Tao Lim2, An Ting Tay3
1National Centre for Infectious Diseases, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore.
概括
静脉注射雷梅西维尔在住院COVID-19患者中没有显著减少长期的后续症状或持续的症状. 这项研究发现,治疗和未治疗组之间的心血管,神经,呼吸或自身免疫诊断没有差异.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 住院治疗COVID-19可能会导致长期健康问题 (sequelae).
- 抗病毒疗法用于管理严重的COVID-19,但它们对长期结果的影响需要评估.
- 之前的研究表明,对于COVID后疾病治疗的有效性,结果各不相同.
研究的目的:
- 评估静脉注射雷梅西维尔对COVID-19住院治疗后长期后果的影响.
- 为了调查新出现的心血管,神经,呼吸系统和自身免疫诊断的风险.
- 为了确定雷梅西维尔是否会影响住院后持续的症状.
主要方法:
- 在新加坡使用国家登记册和医疗保健索赔的以人口为基础的回顾性队列研究.
- 包括2021年9月至2023年7月期间因COVID-19住院的成年新加坡人,他们接受了静脉注射的remdesivir.
- 根据基线差异进行调整,使用重叠加权重,并比较了雷梅西维尔治疗和未治疗组之间的结果.
主要成果:
- 分析了30175例住院病例;37.6%的人接受了remdesivir. 该队列在很大程度上接种了疫苗 (88.9%),并增强了 (60.5%),大多数感染发生在Omicron波 (77.4%) 期间.
- 住院后长期新发病诊断 (心血管,神经,呼吸道,自身免疫) 在里德西维尔治疗和未治疗组之间在住院后300天内没有发现显著差异.
- 雷梅西维尔治疗也没有显著影响住院后300天症状的持续时间.
结论:
- 静脉注射雷梅西维尔在住院COVID-19患者中没有显著降低长期多系统性后果的风险.
- 抗病毒治疗对长期症状的持续性也没有显著影响.
- 研究结果表明,remdesivir在增强的住院COVID-19队列中可能无法有效预防长期并发症.
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