在口腔喉外的Epstein-Barr病毒阴性霍奇金淋巴瘤
Travis Scott Smith1, Nathaniel Hunter1, David Allen2
1University of Texas McGovern Medical School, Houston, Texas, USA.
BMJ case reports
|June 22, 2025
概括
本病例报告详细介绍了一种罕见的埃普斯坦-巴尔病毒阴性淋巴细胞丰富的古典霍奇金淋巴瘤在头部和部. 早期诊断和治疗导致成功管理这种不常见的口腔瘤恶性病.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 头部和部手术 头部和部手术
背景情况:
- 在头部和部的异位古典霍奇金淋巴瘤 (cHL) 是罕见的.
- 淋巴细胞丰富 (LR) cHL亚型在这个位置非常罕见,文献有限.
- 精确诊断罕见的头恶性瘤对于有效的患者管理至关重要.
研究的目的:
- 报告第一个记录的埃普斯坦-巴尔病毒阴性 (EBV阴性) 淋巴细胞丰富的古典霍奇金淋巴瘤 (LR cHL) 发生在口腔大.
- 突出罕见的外节淋巴瘤所带来的诊断和治疗挑战.
- 强调及时诊断对治疗方案和患者结果的影响.
主要方法:
- 一个案例研究中年男性呈现一个口腔大质.
- 诊断程序包括磁共振成像 (MRI) 和通过跨口腔喉切除术进行组织病理学检查.
- 在现场杂交 (EBER1) 用于爱斯坦-巴尔病毒 (EBV) 测试.
主要成果:
- 组织病理学证实了在口腔质中富含淋巴细胞的古典霍奇金淋巴瘤 (LR cHL).
- 爱斯坦-巴尔病毒 (EBV) 测试是负的 (EBER1负).
- 患者在切割27个月后经历了鼻喉的局部复发,通过进一步切除和化疗成功管理,14个月后没有疾病的证据.
结论:
- 这一病例代表了EBV阴性LR cHL在口腔喉中的第一个有记录的实例,随后出现鼻复发.
- 这些发现强调了迅速识别和管理罕见的头恶性瘤的重要性.
- 有效的治疗策略,包括手术切除和化疗,即使在罕见的淋巴瘤亚型中也可以带来良好的结果.
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