酒精消费量,饮酒模式和多病症的发展轨迹:一个前性队列研究
Weiqi Wang1, Zhen Tian1, Qiaoyu Wang2
1National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Molecular nutrition & food research
|June 23, 2025
概括
过度饮酒和不吃饭的饮酒增加了患非传染性疾病 (NCD) 的风险,进展到多病症和死亡率. 红酒消费没有显示类似的关联.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 慢性疾病研究 慢性疾病研究
背景情况:
- 非传染性疾病 (NCDs) 构成了全球重大健康负担.
- 了解从单一非传染性疾病向多重疾病的进展及其对死亡率的影响至关重要.
- 酒精消费是一种可修改的风险因素,与各种健康结果有关.
研究的目的:
- 调查酒精消费量和饮酒模式对从健康到第一个非传染性疾病,随后的多病症和死亡的轨迹的影响.
- 分析不同类型的酒精 (烈酒,酒,红葡萄酒) 与饮酒习惯 (带/不带食物) 与疾病进展之间的关联.
主要方法:
- 用英国生物银行队列 (N = 284,744) 进行分析.
- 采用多状态模型来估计酒精对整个多病态路径的影响.
- 定义多病症是至少有两个非传染性疾病 (癌症,慢性呼吸道,心血管疾病,2型糖尿病) 的存在.
主要成果:
- 与非饮酒者相比,有害饮酒者在多病性途径的所有五个过渡中都表现出更高的风险.
- 烈酒和酒的消费显示出类似的不良关联,而红葡萄酒则没有.
- 与饮酒与食物相比,不吃饭喝酒与四个过渡期的风险更高,不包括因多病症而导致的死亡.
结论:
- 消费的酒精量和饮酒模式都对多种疾病发展的几乎所有阶段都有重大影响.
- 公共卫生战略应考虑酒精消费的数量和背景,以减轻NCD进展和死亡率.
- 这些发现强调了饮食背景在饮酒期间对疾病风险的重要性.
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