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Updated: Sep 18, 2025

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea

Published on: November 9, 2016

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准备好使用和粉末阿博托毒素A对骨线的比较:一个随机的,受控的,三盲临床试验

Silvio Ventura da Silva Junior1, Maria Luiza Boechat Borges Neves1, Alfonso Sanchez-Ayala2

  • 1Department of Dentistry, Ingá University Center, Uningá, Maringá, Paraná, Brazil.

Journal of cosmetic dermatology
|June 23, 2025
PubMed
概括

准备好使用的肉毒素A (RTUaboBoNT-A) 的疗效和耐用性与标准的肉毒素A在 glabellar 线上具有可比性. 虽然这两种治疗都是安全的,但RTUaboBoNT-A与注射疼痛增加有关.

关键词:
这种毒素是abobotulinumtoxinA.一种类型A的肉毒毒素毒素.皮肤上的纹.准备好使用的abobotulinumtoxinA

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Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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Peripherally and Centrally Acting Muscle Relaxants: A Comparison

Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
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