国际泌尿病学学会关于癌症前体病变的共识. 工作组1:前列腺
Kenneth A Iczkowski1, Angelo M De Marzo2, Neeraj Agarwal3
1Department of Pathology and Laboratory Medicine, University of California-Davis Health, Sacramento.
The American journal of surgical pathology
|June 23, 2025
概括
病理学家将不再报告低级别的PIN. 将报告多焦点高度前列腺内皮瘤 (HGPIN),但不会与癌症相邻的HGPIN. 内导管癌 (IDC) 标准得到了改进.
科学领域:
- 尿路病理学 尿路病理学
- 前列腺癌的前体是前体的前体.
- 诊断标准 标准化 标准化
背景情况:
- 准确识别前列腺癌前体对于患者管理至关重要.
- 目前关于报告前列腺内皮质瘤 (PIN) 和相关病变的指导方针存在模两可.
- 报告实践的标准化提高了临床可行性,减少了诊断的变化.
研究的目的:
- 评估和提供关于5种前列腺癌前体的报告的共识建议.
- 改进诸如导管内癌 (IDC) 和非典型导管内扩散 (AIP) 等病变的诊断标准.
- 引导病理学家专注于前列腺活检和切除中的临床可行的发现.
主要方法:
- 2024年9月召开ISUP癌症先驱者会议的第一组工作组.
- 审查了最近的证据,并询问了五种前体病变的当前病理实践.
- 使用基于共识的投票系统,建议需要67%的批准.
主要成果:
- 达成共识,反对报告低级别PIN.
- 在癌症附近不需要HGPIN报告. 建议报告多焦点隔离的HGPIN.
- 完善的IDC标准:密集的cribriform/固体扩散不需要明显的异型. Cribriform HGPIN被重新指定为AIP,需要单独评论或与1级癌症一起评论.
结论:
- 建立了前列腺癌前体,特别是HGPIN和IDC的标准报告.
- 澄清了非典型导管内扩散 (AIP) 报告,并对其存在提出了具体建议.
- 报告PIA和AAH/腺作为相关的负值没有达成共识.
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