病和单细胞测序研究:从2015年到2024年的文献分析分析
Yaotan Li1,2, Jinyi Hou1,2, Xinghua Zhang1,2
1Dongzhimen Hospital, Affiliated to Beijing University of Chinese Medicine, Beijing, China.
Renal failure
|June 23, 2025
概括
单细胞RNA测序 (scRNA-seq) 正在改变病研究. 本文献分析显示了scRNA-seq研究的快速增长,揭示了个性化治疗的关键趋势和机会.
科学领域:
- 脏医学和生物信息学
- 基因组学和转录基因组学
背景情况:
- 单细胞RNA测序 (scRNA-seq) 提供了高分辨率的细胞分析,超越了病研究中的批量测序限制.
- scRNA-seq阐明了疾病进展,细胞间通信和细胞异质性,这对于理解病机制至关重要.
- 这项技术有助于开发向疗法和针对脏疾病的个性化治疗策略.
研究的目的:
- 在病研究中使用scRNA-seq的出版物进行文献分析.
- 从2015年到2024年,系统地评估研究环境,并确定scRNA-seq病研究中的新兴趋势.
主要方法:
- 对1210篇关于脏疾病中scRNA-seq的出版物的图书统计分析.
- 数据来源于科学网络核心集合 (WoSCC) 数据库.
- 使用R包进行的分析:Bibliometrix,VOSviewer和CiteSpace.
主要成果:
- 中国在出版物方面处于领先地位,并观察到持续的年度增长.
- 主要的贡献机构包括哈佛医学院,孙中山大学和上海通大学.
- 关键的研究领域包括scRNA-seq,疾病进展/机制,基因调节/表达,免疫疗法和scRNA-seq创新.
结论:
- 病研究中的scRNA-seq领域正在经历快速增长和演变.
- scRNA-seq应用为推进对病机制的理解提供了重大机会.
- 这项技术对于开发脏疾病的新个性化治疗策略至关重要.
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