外源抗分泌因子对急性腹的狗的影响:一项随机,安慰剂控制,双盲研究
Caroline Harlos1, Johanna Holmberg2, Jens Häggström2
1Anicura Albano Animal Hospital, Danderyd, Sweden.
The Veterinary record
|June 23, 2025
概括
抗分泌因子 (AF) 补充剂没有改善急性腹的狗的结果. 这项随机对照试验发现,在接受AF和接受安慰剂的狗之间,便得分或住院时间没有显著差异.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 动物健康 动物健康
背景情况:
- 抗分泌因子 (AF) 是一种内源蛋白质,参与流体和离子运输.
- 在人类中,AF已经证明有效地减少了腹持续时间.
研究的目的:
- 评估口服抗分泌因子 (AF) 补充剂在治疗狗急性腹中的有效性.
- 为了确定AF是否会降低便分数,排便频率或住院时间.
主要方法:
- 一个随机的,安慰剂控制的,双盲的临床试验,涉及72只急性腹的狗.
- 狗接受了AF或安慰剂作为每日食品添加剂,持续5天.
- 测量结果包括布里斯托尔便图 (BSC) 评分,排便次数和住院时间.
主要成果:
- 在AF和安慰剂组之间,没有观察到BSC得分,每日排便或住院几天的显著差异.
- 在AF组的狗比安慰剂组的狗年龄大得多,这是一个潜在的混因素.
- 基线的差异包括安慰剂组中血的发病率较高.
结论:
- 在这项研究中,口服补充抗分泌因子 (AF) 对急性犬腹没有显示出治疗益处.
- 在AF组中,狗的年龄较大可能影响了研究的结果.
- 可能需要进一步的研究来探索AF在狗胃肠道健康中的作用.
更多相关视频
相关概念视频
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
335
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
335
Drugs for Treatment of Diarrhea-Predominant IBS
313
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
313
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
207
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
207
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
325
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
325
Inflammatory Bowel Disease IV: Pharmacological Management
204
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
204


